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Specifically, AX upregulated peroxisome proliferator-activated receptor- coactivator 1-alpha (PGC-1) and mitochondrial transcription factor A (TFAM), key regulators of mitochondrial DNA replication and transcription, as well as oxidative phosphorylation (OXPHOS) complex proteins, resulting in increased mitochondrial DNA content and ATP production

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These infections are associated with adverse outcomes like human immunodeficiency virus (HIV) transmission risk, preterm birth, high susceptibility to infection of human papillomavirus (HPV), as well as higher probabilities of developing cervical, endometrial, and ovarian cancers as shown in Figure 1 (Ciberia et al., 2021)