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Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times
Although Cagrilintide interacts with amylin receptor complexes rather than incretin receptors directly, researchers frequently compare its signaling profile with incretin based peptides because these hormone systems operate within overlapping metabolic regulatory networks
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R., Catapano, A
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