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Rather than daily injections, the protocol requires a heavier 2.5 mg systemic dose injected twice per week

10.1038/s41586-021-03539-7 114 MaoL.YouJ.XieM.HuY.ZhouQ

Cavazos recognizes that even mild B12 insufficiency can significantly impact quality of life, often in ways that conventional medical testing may not detect until deficiencies become severe