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Signs of toxicity of levodopa-carbidopa, include dyskinesia, hallucinations, and psychosis

10.3389/adar.2023.11628 147 WengM

This hippocampal hyperactivity can be normalized by hippocampal chemical inactivation [26, 32], or by pharmacologically facilitating GABA signaling through direct hippocampal infusion of either a nonselective (the benzodiazepine midazolam) [33] or selective positive allosteric modulator (PAM) for 5-subunit-containing GABA A receptors [33, 34]

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