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Administering these vitamins via injection bypasses gastrointestinal absorption barriersuseful for patients with pernicious anemia, post-gastrectomy states, chronic metformin or acid-suppressing therapy that impairs B12 absorption, or conditions that reduce intestinal uptake

It has been proposed that ATXN3 contributes to facilitate the proteasomal degradation of ubiquitylated proteins by editing polyubiquitin chains of a subset of substrates prior to digestion [69] and to protect others from degradation [70,71,72]

Vitamin B12 exists in several forms and contains the mineral cobalt [1-4], so compounds with vitamin B12 activity are collectively called cobalamins