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Recombinant His-tagged AtGrxS15, AtGrxC1 and roGFP2 were also expressed and purified according to established protocols 34,36

2.2 Inclusion criteria We mainly included English-language literature published between 2004 and 2024

Given the complexity of the disease, it is therefore not surprising that dissecting cause and effect is not a simple matter

425 In two separate preclinical trials, tranilast exhibited promising urate-lowering effects along with a reduction in inflammation associated with urate crystal deposition