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Highlights NLRP6 controls lung inflammation from cigarette smoke through CXCL1/CXCL5-mediated neutrophilic influx NLRP6-mediated lung inflammation is dependent on the inflammasome NLRP6 expression in airway epithelial cells controls lung inflammation from cigarette smoke Cigarette smoke exposure alters gut microbiota Impaired lung inflammation in cigarette smoke-exposed Nlrp6-deficient mice is transferable to wild-type mice by co-housing experiments or fecal microbiota transplantation Gut microbiota from Nlrp6-deficient mice limit neutrophilic lung inflammation Introduction Chronic obstructive pulmonary disease (COPD) is a severe inflammatory disease characterized by airway obstruction due to bronchial immune cell recruitment and mucus secretion, resulting in impaired lung function

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