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This signature appeared to shift the balance of T cell responses away from an effector response and toward a Treg response, which helped suppress IFN-producing CD4+ T cells (110)

The downstream effects are dramatic: keratinocyte proliferation and differentiation accelerate, the epidermis compacts and normalizes, melanin transfer is disrupted (fading pigmentation), and dermal fibroblasts are stimulated to produce new collagen while matrix-degrading enzymes (MMPs) are suppressed

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