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The aim of this study was, therefore, to explore the possible association of global UV levels on the prevalence of polymorphisms in key folate metabolism enzymes

Liver detoxification: Most concentrated in the liver, where it binds to toxins (heavy metals, drug metabolites, environmental pollutants) and helps your body process and eliminate them

Under conditions of stress, Kelch-like ECH-Associated Protein 1 (KEAP1), which is a cytosolic inhibitor of Nrf2, is oxidized, leading to stabilization and translocation of Nrf2 into the nucleus, where the transcription factor activates expression of genes crucial to antioxidant defense [68]

these models require much higher cell numbers to build-up a tight monolayer and longer cultivation times to reach stable TEER values (Cucullo et al., 2002, 2011)