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In line with these observations, exposure of the SW480 colorectal cancer cell line to n -acetylcysteine yielded a synchronous upregulation of 3-MST and SQR expression and activity

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Using Mendelian randomization and UK Biobank data, researchers found that this biological response signature is causally associated with a significantly lower risk of Ischemic Heart Disease (OR = 0.87) and diabetes (OR = 0.66), cementing berberine's status as a powerful cardioprotective agent

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