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Even with a small amount of nicotine in your system, the negative side effects can include: Increase in heart rate Higher dependency, leading to stress and anxiety without vaping Nervous disposition without nicotine, which can impact levels of sleep Impact on mental health, changing mood levels Nicotine on the direct application in humans causes irritation and burning sensation in the mouth and throat, increased salivation, nausea, abdominal pain, vomiting and diarrhoea Even if vaping with nicotine is seen as a positive alternative to smoking because it reduces the risk of cancer and can help improve short term benefits such as your energy levels or breathing compared to smoking, when youre addicted to something, whether thats coffee, or alcohol, its hard to turn your mind and body away from consuming that substance