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It facilitates the dimerization of c-Met receptors, which triggers signaling cascades involved in neuronal growth, synaptic plasticity, and synaptogenesis

Moreover, a caspase B (CTSB)-responsive programmed targeted delivery system D&R-HM-MCA can achieve TAM-targeted delivery, and the outer angiopep-2 modification can be cleaved off by CTSB-responsive peptides when it reached the tumor site, exposing the para-aminophenyl--d-mannopyranoside (MAN) modification which can further recognize glucose transporter-1 (GLUT1) on tumor cells and macrophage mannose receptors (MMR) on TAMs, inducing TAMs polarization from the anti-inflammatory M2 phenotype to the pro-inflammatory M1 phenotype thereby improving antitumor immune responses (59)

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