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Bone morphogenetic protein 6 (BMP6) plays a crucial role in regulating ferromodulin expression, and targeting this pathway presents a promising therapeutic strategy [98]

Annu Rev Pharmacol Toxicol 63:249272

OARSI-FDA initiative: defining the disease state of osteoarthritis

This GHR upregulation sensitises local cells to circulating GH, potentiating GH-induced JAK2/STAT signalling and stimulating collagen matrix synthesis, IGF-1 production, and fibroblast proliferation providing a mechanism through which BPC-157 engages the GH/IGF-1 axis at the tissue level without altering systemic GH secretion