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Compound 14 should be singled out from the others, since it shows good inhibitory activity (IC 50 = 3.56 M), which is almost 2.5 times more effective than allopurinol (IC 50 = 7.86 M), a drug that has already been consolidated in the treatment of hyperuricemia (Figure 7)

INTRODUCTION Gout is the most common form of inflammatory arthritis and results from the deposition of monosodium urate crystals in joints and surrounding tissues

Results typically come back within 3-5 days

Four different mutations in the heavy subunit have been identified in four families affected by gamma-glutamylcysteine synthetase deficiency [1, 2, 4, 5]