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Research in cardiac ischemia models showed that TB-500 reduced pro-inflammatory cytokines (TNF-alpha, IL-1beta) at injury sites, potentially creating a less hostile environment for repair cells to operate in. Think of TB-500 as upgrading the cellular infrastructure giving repair cells the physical capacity to do their job

The least COX-2 expression occurred in the diclofenac sodium group and the 1.3 bis( p -Hydroxyphenyl)urea at doses of 100 and 200 mg/Kg BW

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