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Preclinical Research Dosing Models Animal model studies have explored GHK-Cu at the following ranges: Topical (in vitro/ex vivo): 10100 M concentrations in cell culture media Subcutaneous (rodent models): 15 mg/kg body weight, administered 12x daily Wound healing models: Local application at 110 g/wound site Reconstitution for Research GHK-Cu is typically supplied as a lyophilized powder

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In some embodiments, the otic formulation or composition comprises about 0.06% by weight of the silicon dioxide

Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis