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Importantly, this form of plasticity can be initiated by any event that causes strong activation of a neuron, firing, and a rise of [Ca 2+ ] i to a sufficiently high level, meaning that it is capable of being engaged by almost any activity pattern that induced any of the diverse forms of homosynaptic plasticity discussed above

FD&C Act Provisions that Apply to Human Drug Compounding

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Rapid acetylators were competent in isoniazid acetylation but the drug was cleared less efficiently in the slow acetylator group, which resulted in elevated serum concentration and led to adverse neurologic side effects due to an accumulation of unmetabolized drug (Brockton et al., 2000)