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[16] Although cyanocobalamin lacks a defined upper-toxicity threshold due to its water solubility and renal elimination, exceptionally high cumulative doses have been temporally associated with acneiform eruptions, altered potassium homeostasis, and theoretical thrombotic risk, emphasizing the importance of evidence-based dosing

Description For use in Vitamin B-12 deficiency associated with cobalt deficiency in cattle and sheep and for Vitamin B-12 deficiency associated with inadequate Vitamin B-12 intake or intestinal malabsorption in swine and horses

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A 2003 mouse study specifically on Epitalon reported that treatment did not influence mean lifespan in female Swiss-derived SHR mice, though there were effects on chromosomal aberrations, estrous function, and spontaneous tumor incidence