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Prescription and administration: Once B12 deficiency is confirmed, GPs prescribe hydroxocobalamin injections according to standardised protocols: Standard loading regimen: 1mg intramuscularly three times weekly for two weeks Neurological involvement: 1mg intramuscularly on alternate days until no further improvement Maintenance therapy: 1mg every three months for life in pernicious anaemia or malabsorption conditions (or every two months if there was neurological involvement) Injections are typically administered by practice nurses at GP surgeries
Ascorbic acid injection: MedlinePlus drug information
Furthermore, these trials have limitations, including small sample sizes, wide age ranges of participants, short treatment durations, and heterogeneity in patient treatment (162)
Vitamin B6: Pyridoxine Necessary for the production of melatonin and restful sleep
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