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Glutathione deficiency or dysregulation is a well-established biochemical hallmark in diverse chronic diseases, including neurodegenerative conditions, Parkinsons, Alzheimers, mental health, cognitive decline, and metabolic and immune dysfunction, among others (17)

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Similarly, 2+ concentration induced by LCAC superfusion ( 2+ release from the SR, regardless of RyR2-dependency, LCACs appear to alter both SR Ca 2+ uptake and release in a manner that promotes cytosolic Ca 2+ overload and can be translated to other reports of arrhythmogenic and inotropic effects of LCACs