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The practical rationale for combination protocols is straightforward: BPC-157 targets local tissue repair (particularly GI, musculoskeletal, and neural) through signaling pathways that promote growth factor expression and cell survival at injury sites, while TB-500 operates more systemically particularly through vascular remodeling, cardiac progenitor activation, and direct anti-inflammatory cytokine modulation

Given the theoretical cancer concern (disrupting senescence surveillance) and absence of human pharmacokinetic data, caution is warranted

ClinicalTrials.gov , 2015

Timing Baseline Marker CRP Why it matters May help frame systemic inflammation when injury, skin, or tissue-repair symptoms are part of the protocol