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Several factors govern the ability of liver enzymes to assist in diagnosis, including their (1) tissue specificity, (2) subcellular distribution, (3) relative activity of enzyme activity in liver and plasma, (4) patterns of release, and (5) clearance from plasma

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In 1999, in a notable discovery, the endogenous ligand of the centrally localized GHS-R1a was identified in peripheral tissue ( In addition to promoting GH secretion ( Acyl-modified hormone: ghrelin Ghrelin, a peptide hormone isolated and purified from the rat stomach in 1999, is a endogenous ligand of the GHS receptor (now referred to as the ghrelin receptor) ( ghre , meaning to grow, reflecting its role in stimulating GH secretion

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