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In addition, GSH depletion and GSSG accumulation due to oxidative stress induce apoptosis by activating the SAPK/MAPK pathway [18]

Aguilera G, Rabadan-Diehl C

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Although glutathione (GSH) is a potent antioxidant capable of mitigating oxidative stress, its therapeutic potential is limited by its instability due to rapid degradation by -glutamyl transpeptidase (-GT)