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It can occur due to certain fungal or bacterial infections, or when saliva becomes trapped on the sides of your lips ( summary In addition to particular nutrient deficiencies, chapped lips may be caused by several other environmental and health conditions

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Metformin, commonly used to treat type II diabetes, has been shown to modulate gut microbiota composition, reducing the relative abundance of bacteria that encode choline TMA lyase, and thereby attenuating atherosclerosis [164]