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Rodents overexpressing USP22 or lncRNA PART1 were well resistant to I/R-induced oxidative stress and cardiac injury, which may be partly attributed to the elevated GSH content in the myocardium [251, 252]

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Mitochondrial glutathione depletion is directly linked to oxidative damage to mitochondrial DNA, impaired cellular energy production, and the patterns of age-related functional decline observed across tissues