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Analysis using the PANTHER GO Slim program to reveal the biological processes with which these proteins are involved reveal immune system activation (complement activation, antimicrobial humoral response, activation of immune response, immunoglobulin mediated immune response, leukocyte-mediated immunity, and receptor-mediated endocytosis, among others

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A third HFE genotype is related to the mutation S65C that may lead to increased serum iron and ferritin levels