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UPLC-HRMS analysis UPLC-HRMS analyses were performed using a Waters ACQUITY UPLC I Class system fitted with a Waters ACQUITY UPLC BEH C 18 column (2.1 100 mm, 1.7 m particle size, Waters Corporation, Milford, MA, USA, catalogue #186002352), and coupled to a Xevo G2S QTOF mass spectrometer (Waters Corporation, Manchester, UK, SN: YDA 375) with an electrospray ionization (ESI) source operated in ESI positive ionization mode

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Encouragingly, multiple glutamate-based compounds have entered clinical testing, with some compounds recently advancing to phase III trials

They are not ready for a six-month custom development cycle