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Subeffective dosages of metformin combined with L-NAME and 7-NI reduced CQ-induced scratching behavior, whereas L-arginine reversed the effect, indicating the involvement of the NO pathway in pruritus [14, 15]

Populations who might particularly benefit from L-carnitine supplementation include older adults experiencing age-related decline in natural carnitine production, athletes with high energy demands, and those with specific metabolic or cardiovascular conditions

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