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B12 shots have been shown to boost mood, increase energy, and provide an improved sense of well-being

Energy and Well-Being: Vitamin B12 is known for its role in energy production and maintaining a healthy nervous system

Exploring the chemical space of protein glycosylation in noncovalent protein complexes: an expedition along different structural levels of human chorionic gonadotropin by employing mass spectrometry

The reduction in red blood cell production is why patients with B12 deficiency report feeling so extremely fatigued (even under the slightest of efforts), sort of like the fatigue you get from altitude sickness