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Indeed, neuronal Ogt overexpression and augmented O-GlcNAc levels in the aged hippocampus have been demonstrated to partially ameliorate age-related deficits in spatial learning and memory, along with associative fear memory in aged mice [34]

However, it may be challenging to accurately control the dosage or adjust it to specific needs

For example, triple-ligand systems have demonstrated: These systems often combine different mechanisms such as amino acids, peptides, and metabolic ligands to optimize uptake