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Highdose IV protocols (5001,500 mg daily for ~10 days) have been used in openlabel studies for substance use disorder, with reports of reduced cravings and improved mood in followups [2] [9]

A mixed model for repeated measurements was used to input any missing data from test subjects that discontinued treatment or required a dose of rescue medication

Like other copper-binding tripeptides, its biological effects are proposed to occur through both the peptide backbone and the copper ion it coordinates with the copper contributing to enzymatic cofactor activity and oxidative stress modulation