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This suggests that rapamycin could serve as a potential therapeutic approach to reduce the risk of developing Alzheimer's disease (AD) in individuals with DS (Curtis et al

Overall, irreparable damage to membranous organelles, spindle microtubules, cellular DNA, and the heat shock system itself leads to profound dysfunction of gametes and embryos and even apoptotic cell death, all of which adversely impact fertility (84, 85, 107, 109, 110, 152, 153)

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