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However, if deep vertical wrinkles around the mouth or severe hyperpigmentation have formed, the patient needs to use more intensive treatments

Human studies further confirmed systemic low-grade inflammation in smokers, evidenced by elevated serum levels of interleukin-1 (IL-1), IL-6, tumor necrosis factor- (TNF-), and C-reactive protein (CRP) [33, 34]

Why This Matters No Glue, No Chemicals, No Tobacco: That means no nicotine

In case you needed more evidence, the largest review of evidence to-date, conducted by Cochrane, found high-certainty evidence that E-Cigarettes are more effective for quitting smoking than traditional forms of nicotine replacement therapy, like the nicotine patch and nicotine gum