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The original observation was specific and odd: an albumin-bound serum factor from young donors caused aged human liver-tissue explants to resume protein synthesis at rates characteristic of younger tissue [1]

[Reducing hyperpigmentation]:higher concentrations, kojic acid is known to reduce the appearance of dark spots, age spots, and other forms of hyperpigmentation.,Kojic acid may help to even out the skin tone by reducing the appearance of blemishes and dark spots

Studies have shown that trypsin induces the release of calcium ions from vascular endothelial cells, causing coronary artery-dependent vasodilation and reducing the contractile sensitivity of smooth muscle [79]