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Antioxidant responses and cellular adjustments to oxidative stress
3 Urolithin A and sleep: current evidence For this mini-review, we utilized a hypothesis-based scoping review method where we conducted a search on PubMed, Scopus and Ovid utilizing the terms urolithin A and sleep, urolithin A and circadian, and urolithin A and serotonin or tryptophan. Our inclusion criteria were (1) original research articles, (2) published in English, (3) utilizing isolated urolithin A (no mixtures or parent polyphenols) and (4) including at least one outcome relevant to sleep or sleep-related biological mechanisms, with no constraints on publication date
Without human PK/PD, there is no established relationship between an administered amount and a plasma concentration, no half-life, no tissue-distribution data, and therefore no rational basis for any human dosing
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