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Richardson DR, Lok HC (2008) The nitric oxide-iron interplay in mammalian cells: transport and storage of dinitrosyl iron complexes

Further, sebum is essential to maintain and protect skin hydration

Losartan effectively attenuated hyperactivity and anxiogenic behaviors in mice as seen in the EPM, social-interaction tests, and open field tests (OFT) (51) (50)

This suggests that levels of free heme alone are not sufficient to immediately change the oxidative state of the parasite, although it is recognised that chemical inhibition of cysteine proteases may have additional impacts on the parasite, and does not perfectly mimic the heme depletion caused by K13-mediated alteration of hemoglobin uptake