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V.HamburgerM.OufirM
doi: 10.1016/j.atherosclerosis.2014.03.009 66
In preclinical models, BPC-157 is investigated for its activity across several interconnected signaling cascades, including the VEGFR2/eNOS angiogenic axis, the FAK-paxillin pathway in tendon fibroblasts, and ERK1/2-mediated transcription factor activation
Previous studies suggest that GCL is localized to the chloroplasts and GS is localized both to chloroplasts and cytosol in plant cells (Hell and Bergmann, Arabidopsis suggests that GCL and GS are each encoded by a single gene with alternate transcription start sites leading to either plastid-targeted or cytosolic protein (Wachter et al., Arabidopsis leaf tissue shows that GCL is localized to the chloroplast and that GS is found within chloroplasts and the cytosol (Figure 2)
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