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Since many e-liquids contain nicotine, which is known to affect testosterone levels, there remains a concern

Specifically, it can interfere with the effects of some medication treatment regimens, including interferon beta 1a (sold as Avonex, Rebif, and Plegridy) and a disease-modifying drug for MS treatment called Tysabri (natalizumab)

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A hygienist can also apply numbing agents during prophylaxis cleanings too