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Manufacturers tout the devices as healthier than cigarettes and as a way to kick a nicotine addiction, but public health officials and legislators are concerned about health risks

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Systems toxicology analyses detected biological effects of nicotine exposure, which included up-regulation of the xenobiotic-metabolizing enzymes CYP1A1 and FMO3 in the lung and metabolic effects, likely interlinked with a generalized stress response to nicotine present in the exposure aerosols [34]