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Description

J Am Acad Dermatol (2017) 76(3):37790

Dalton TP, Chen Y, Schneider SN, Nebert DW, Shertzer HG: Genetically altered mice to evaluate glutathione homeostasis in health and disease

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Activation of the NRF2/SLC7A11/GPX4 signaling pathway leads to elevated GSH levels, reduced MDA and ROS accumulation, suppression of neuronal ferroptosis, lipid peroxidation, and amino acid antioxidant dysfunction, ultimately mitigating neuronal injury