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Subsequently, there may be an expansion of apoptosis involving the interaction of either membrane-bound or soluble Fas ligand (sFasL) with its receptor Fas

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However, this binary classification has faced recent criticism ( In contrast, M2 macrophages, induced by IL-4, IL-13, IL-10, or glucocorticoids, produce anti-inflammatory cytokines, primarily TGF- and IL-10 ( Figure 6 ) ( Figure 6 This advanced classification provides a framework for understanding the diverse roles of macrophages in regulating ferroptotic

We posit that recently described functions of KLF9 in mediating inflammatory responses underlie the differences