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Unlike high-dose GH administration, sermorelin is not known to cause significant fluid retention, carpal tunnel syndrome, or organomegaly in the doses used for deficiency treatment

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When cardiolipin becomes oxidized, it migrates to the outer membrane, where it can interact with cytoplasmic amyloidogenic proteins to facilitate the formation of pores in the mitochondrial membrane, and, ultimately, to trap mitochondrial debris from aged mitochondria within fibrillar extracellular deposits such as Lewy bodies (Seneff et al., 2025b)