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Ferroptosis and cellular senescence Typically, moderate and sustained levels of ROS induce cellular senescence by causing DNA damage, oxidation of proteins and lipids, and subsequently activate cell cycle arrest-related signaling pathways, such as p53-p21 [132]

doi: 10.1016/j.atherosclerosis.2018.06.882 80 RoudiHSSafaeiRDabbaghiMMFadaeiMSSaberifarMSakhaeeKet al

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MDA was measured using the Thiobarbituric Acid Reactive Substances (TBARS) assay kit from Cayman Chemicals (Item No.10009055) following the manufacturers protocol