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There is a piece of evidence that continuous infusion of AMPA in the lumbar spinal cord of adult rats resulted in excessive activation of Ca 2+ -permeable AMPARs (CP-AMPARs), leading to progressive hindlimb paralysis and bilateral motor neuron (MN) degeneration [52]

Similarly, lepodisiran has shown well-tolerated and dose-dependent reductions in serum Lp(a) concentrations, with a Phase III trial currently recruiting participants and expected to be completed by 2029 (NCT06292013 and NCT04914546)