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Astrocytes provide neurons with precursors for the three amino acids that are needed for GSH synthesis

Administration of Sch B significantly inhibits glycogen synthase kinase 3 (GSK3) activation in the hippocampus and cortex neurons of triple-transgenic Alzheimers disease (3 Tg AD) mice, upregulates Nrf2, GPX4, and ferroptosis suppressor protein 1 (FSP1) expression, reduces levels of MDA, Fe 2+ , ROS, and tumor necrosis factor alpha (TNF-), thereby suppressing neuronal ferroptosis and neuroinflammation and improving learning and memory performance

They are typically administered via subcutaneous injection, though some may be available in oral, nasal, or topical forms

While excessive levels of ROS can cause apoptosis in cancer cells, moderate ROS levels promote tumor development and progression (49)