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Unlike IL-6 and IP10, which have been experimentally demonstrated to promote EBV reactivation by our group, TNF- significantly inhibited EBV reactivation by acting on the TNFR1 receptor

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Increased intra-articular iron levels, lipid peroxidation, and weakened antioxidant defenses promote ferroptosis, worsening cartilage degeneration, and joint function loss ( Although research on the precise mechanisms and clinical relevance of ferroptosis in OA is still in its infancy, the volume of related studies is growing swiftly (Yang et al., 2021