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Both amylin and GLP-1 receptor agonists act within this region

Safety Takeaway Due to incomplete safety data, the theoretical risk of cancer acceleration, and the potential for abuse, its use must be strictly limited to controlled research settings

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It has been proposed that all children and adults with AIH and cholestatic clinical or biochemical profiles (pruritus and/or elevated gamma-glutamyl transferase), non-response to first-line treatments, and those with concurrent ulcerative colitis, should be evaluated for ASC/overlap [29, 42, 183,184,185]