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In rare cases, some people might have severe side effects like: Skin rash, itching, or hives Swelling of the face, lips, or tongue Chest pain or tightness Blue tint to the skin Difficulty breathing or wheezing A swollen, painful area on the leg Dizziness If you experience any of the above side effects, reach out to a healthcare provider immediately

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Additionally, bacteria can develop resistance mechanisms such as modifying membrane charge, producing proteases, altering metabolism, or forming biofilms, which can reduce LL-37s effectiveness