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Research should focus on discovering reliable biomarkers that can be used in clinical settings to assess oxidative stress levels and guide therapeutic decisions

Presumably, the interaction between Arg240 and the carboxylate group of L -DOPA and L -tyrosine (which are most probably of ionic nature as the amide group is mainly charged at the investigated pH) is too strong, resulting in the amide-containing substrates (tyramine and dopamine) being held in place by Arg240

[Abstract]2022 Aug;54:102392