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Additionally, the original McCoy et al

Nicotinamide adenine dinucleotide (NAD + ) is a vital cofactor in mitochondrial bioenergetic pathways, including glycolysis, fatty acid -oxidation, and the TCA cycle 517

Furin plays a major role in oocyte development beyond the early secondary follicle stage and any virus-mediated loss of its proteolytic activity could lead to follicular dysplasia and female infertility 354